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用于干细胞研究的小分子化合物

0115278198032651.jpg用于干细胞研究的小分子化合物

 


  Stemgent® 提供一系列独特的小分子--Stemolecules™ ,这类小分子可用于多能干细胞的自我更新和分化的主要信号通路的分析和调节,诱导多能干细胞(iPS)的细胞重编程,诱导和维持干细胞原始状态。

  Stemolecules™为保证高纯度(≥98%)进行了严格检测,通过NMR和质谱进行结构验证,并且测试了对干细胞的细胞毒性。Stemolecules™ 通常用于提高iPS细胞的产生和维持多能干细胞的培养。

 

Brand

Name

Catalog Number

Size

Stemolecule™

A83-01

04-0014

2 mg

04-0014-10

10 mg

Stemolecule™

ALK5 Inhibitor (RepSox)

04-0015

1 mg

Stemolecule™

All-Trans Retinoic Acid

04-0021

100 mg

Stemolecule™

BI-D1870

04-0051

10 mg

Stemolecule™

BIO

04-0003

2 mg

Stemolecule™

BIX01294

04-0002

5 mg

Stemolecule™

CHIR99021

04-0004

2 mg

04-0004-10

10 mg

Stemolecule™

CHIR99021 in Solution

04-0004-02

2 mg (10 mM)

Stemolecule™

Cyclopamine

04-0022

2 mg

Stemolecule™

DAPT

04-0041

5 mg

Stemolecule™

Dorsomorphin

04-0024

2 mg

Stemolecule™

Doxycycline hyclate

04-0016

10 mg

Stemolecule™

ec23

SRP002

5mg

SRP002-2

2 × 5mg

Stemolecule™

Forskolin

04-0025

10 mg

Stemolecule™

GDC-0941

04-0047

5 mg

Stemolecule™

GSK429286A

04-0049

2 mg

Stemolecule™

IDE-2

04-0027

2 mg

Stemolecule™

KAAD-Cyclopamine

04-0028

100 μg

Stemolecule™

LDN-193189

04-0074

2 mg

04-0074-10

10 mg

Stemolecule™

LDN-193189 in Solution

04-0074-02

2 mg (10 mM)

Stemolecule™

LY411575

04-0054

5 mg

Stemolecule™

PD0325901

04-0006

2 mg

04-0006-10

10 mg

Stemolecule™

PD0325901 in Solution

04-0006-02

2 mg (10 mM)

Stemolecule™

PD173074

04-0008

2 mg

Stemolecule™

Purmorphamine

04-0009

5 mg

Stemolecule™

R(+)Bay K 8644

04-0013

5 mg

Stemolecule™

RG108

04-0001

10 mg

Stemolecule™

SB431542

04-0010

5 mg

04-0010-10

10 mg

Stemolecule™

SB431542 in Solution

04-0010-05

5 mg (10 mM)

Stemolecule™

SB590885

04-0080

2 mg

Stemolecule™

SC1 (Pluripotin)

04-0011

1 mg

Stemolecule™

SHH Antagonist

04-0032

2 mg

Stemolecule™

Sodium Butyrate

04-0005

500 mg

Stemolecule™

Thiazovivin

04-0017

1 mg

Stemolecule™

Valproic Acid

04-0007

5 g

Stemolecule™

WH-4-023

04-0079

2 mg

Stemolecule™

Wnt Inhibitor IWP-2

04-0034

2 mg

Stemolecule™

Wnt Inhibitor IWP-3

04-0035

2 mg

Stemolecule™

Wnt Inhibitor IWP-4

04-0036

2 mg

Stemolecule™

XAV939

04-0046

2 mg

Stemolecule™

Y27632

04-0012

2 mg

04-0012-10

10 mg

Stemolecule™

Y27632 Dihydrochloride Hydrate

04-0012-H-10

10 mg

Stemolecule™

Y27632 in Solution

04-0012-02

2 mg (10 mM)

 


1.

Chen, S., Liu, Z., Lu, S., & Hu, B. (2019). EPEL promotes the migration and invasion of osteosarcoma cells by upregulating ROCK1. Oncology letters, 17(3), 3133-3140.【StemoleculeTM Y-27632】


2.

Zucchini, C., Manara, M. C., Cristalli, C., Carrabotta, M., Greco, S., Pinca, R. S., ... & Gambarotti, M. (2019). ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity. Journal of Experimental & Clinical Cancer Research, 38(1), 1-14. 【StemoleculeTM Y-27632】


3.

Cong, F., Hao, H., Hsieh, M. H. L., Jiang, X., Liu, J., & Ng, N. (2019). Cancer patient selection for administration of wnt signaling inhibitors using rnf43 mutation status. U.S. Patent Application No. 16/259,419.【StemoleculeTM Wnt Inhibitor IWP-2】


4.

Keller, G., & Craft, A. M. (2019). Keller G, Craft A M. Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue. U.S. Patent Application No. 15/977,536. 【StemoleculeTM CHIR99021】


5.

Sun, X., Fu, X., Du, M., & Zhu, M. J. (2018). Ex vivo gut culture for studying differentiation and migration of small intestinal epithelial cells. Open biology, 8(4), 170256.【StemoleculeTM DAPT】


6.

Gieseck III, R. L., Hannan, N. R., Bort, R., Hanley, N. A., Drake, R. A., Cameron, G. W., ... & Vallier, L. (2014). Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture. PloS one, 9(1), e86372.【Stemolecule CHIR99021】


7.

Brick, D. J., Stover, A. E., Nethercott, H. E., Banuelos, M. G., & Schwartz, P. H. (2014). GMP4‐Compatible Production and Expansion of Human Neural Stem Cells. Neural Stem Cell Assays, 35-53. 【StemoleculeTM Y-27632】


8.

Fathi, A., Rasouli, H., Yeganeh, M., Salekdeh, G. H., & Baharvand, H. (2015). Efficient differentiation of human embryonic stem cells toward dopaminergic neurons using recombinant LMX1A factor. Molecular biotechnology, 57(2), 184-194. 【StemoleculeTM SB431542,StemoleculeTM LDN-193189】



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